Antiphospholipid Syndrome (APS) is an autoimmune disorder in which the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies against them. Patients with these antibodies may experience miscarriages and blood clotting disorders, including heart attacks and strokes. APS may occur in people with systemic lupus erythematosus and other autoimmune diseases, or in otherwise healthy individuals.

The Antiphospholipid Syndrome Collaborative Registry (APSCORE) is a national registry and tissue repository for patients with APS. This registry will collect clinical information and blood samples from people with APS.

Condition
Antiphospholipid Syndrome

Further Study Details: 

Expected Total Enrollment:  2000

Registry participants will have a blood sample drawn and will be interviewed about their medical histories. Participants will be asked to return for a follow-up visit after two years. Clinical, demographic, and laboratory data will be collected. Registry resources will be made available to researchers and medical practitioners to support a broad range of research on the causes, diagnosis, mechanisms, and treatment of APS.

The University of North Carolina at Chapel Hill is the coordinating center and an enrollment site for the registry. There are seven other enrollment sites: Ball Memorial Hospital, Muncie, IN; Duke University, Durham, NC; Hospital for Special Surgery, New York, NY; Johns Hopkins University, Baltimore, MD; Morehouse School of Medicine, Atlanta, GA; University of Texas Health Science Center, San Antonio, TX; and University of Utah Health Science Center, Salt Lake City, UT.

Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Antiphospholipid antibodies with or without associated clinical manifestations

Gail S. Buxton      919-966-0572    apscore@med.unc.edu

Georgia
      Morehouse School of Medicine, Atlanta,  Georgia,  30310,  United States; Recruiting
Indiana
      Ball Memorial Hospital, Muncie,  Indiana,  47303,  United States; Recruiting
Maryland
      Johns Hopkins University, Baltimore,  Maryland,  21205,  United States; Recruiting
New York
      Hospital for Special Surgery, Weill-Cornell University Medical Center, New York,  New York,  10021,  United States; Recruiting
North Carolina
      University of North Carolina at Chapel Hill, Chapel Hill,  North Carolina,  27599,  United States; Recruiting
      Duke University Medical Center, Durham,  North Carolina,  27710,  United States; Recruiting
Texas
      University of Texas Health Science Center, San Antonio,  Texas,  78229,  United States; Recruiting
Utah
      University of Utah Health Science Center, Salt Lake City,  Utah,  84132,  United States; Recruiting

Study ID Numbers:  NIAMS-099
Record last reviewed:  March 2005
Last Updated:  March 21, 2005
Record first received:  February 2, 2004
ClinicalTrials.gov Identifier:  NCT00076713
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08