OBJECTIVES: I. Clinically evaluate members from families with dominantly inherited ataxias and collect blood samples for detailed molecular studies. II. Perform detailed clinical evaluations on patients with recessively inherited ataxias.

Condition
Hereditary Ataxia

Further Study Details: 

Expected Total Enrollment:  30

PROTOCOL OUTLINE: Participants undergo a comprehensive clinical and molecular evaluation. Studies include: neurologic evaluation, including magnetic resonance imaging and nerve conduction studies; ophthalmologic exam; audiologic exam, including auditory brain stem evoked response; DNA extraction for lymphoblastoid cell lines; gene mapping; and linkage analysis. A neuropathologic evaluation is conducted postmortem, when possible. Patients with recessive ataxia also receive a developmental assessment.

Genders Eligible for Study:  Both

Criteria

• Patients with recessive ataxia
• Members of families with dominantly inherited ataxia

Texas
      University of Texas Medical Branch at Galveston, Galveston,  Texas,  77555,  United States; Recruiting

Study chairs or principal investigators

Tetsuo Ashizawa,  Study Chair,  Baylor College of Medicine   

Study ID Numbers:  199/11796; BCM-H4499
Record last reviewed:  January 2005
Last Updated:  January 21, 2005
Record first received:  October 18, 1999
ClinicalTrials.gov Identifier:  NCT00004306
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08