Infantile-onset ascending hereditary spastic paralysis is a rare disorder characterized by the progressive weakness and stiffness of arm, leg, and facial muscles. Symptoms of infantile-onset ascending hereditary spastic paralysis begin during infancy or early childhood and slowly worsen. The disorder begins with stiffness and weakness of the legs within the first 2 years of life. Patients are usually wheelchair-bound by late childhood or early adolescence. Weakness and stiffness of arm muscles occur by age 7 or 8 years. During late childhood and early adolescence, patients also experience slow eye movements and difficulty with speech and swallowing. Even though this disorder begins early in life, patients live into their 30s.