Li-Fraumeni syndrome

LFS; Sarcoma family syndrome of Li and Fraumeni; Sarcoma, breast, leukemia, and adrenal gland (SBLA) syndrome; SBLA syndrome

Li-Fraumeni syndrome is a rare autosomal dominant hereditary disorder. It is named after Frederick Pei Li and Joseph F. Fraumeni, American physicians who originally described the syndrome. It increases greatly the susceptibility to cancer. The syndrome is a mutation in the p53 tumor suppressor gene, which normally helps control cell growth. Tumor types The tumors that occur at an increased rate are: Breast cancer Ovarian cancer Osteosarcoma Liposarcoma Leukemia Astrocytoma Meningioma Ga ...