OBJECTIVES: I. Determine whether Cushing's syndrome and stress-induced pseudo-Cushing's syndrome can be differentiated by evaluating endogenous corticotropin-releasing hormone activity.

Condition
Cushing's Syndrome

Further Study Details: 

Expected Total Enrollment:  40

PROTOCOL OUTLINE: Patients undergo a 30-hour infusion of deuterated cortisol with peripheral and petrosal vein measurements of adrenocorticotropin hormone (ACTH) and corticotropin-releasing hormone (CRH). Patients also have a 2-day, low-dose dexamethasone suppression test. Patients with ACTH tumors are referred for pituitary surgery as indicated. Patients without Cushing's syndrome are entered as controls. During scheduled radiologic procedures, these subjects undergo ACTH and CRH sampling from the petrosal vein or cavernous sinus following a deuterated cortisol infusion.

Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

PROTOCOL ENTRY CRITERIA: Suspected adrenocorticotropin hormone (ACTH)-dependent Cushing's syndrome No pregnant women Effective contraception required of fertile women

Oregon
      Oregon Health Sciences University, Portland,  Oregon,  97201-3098,  United States

Study chairs or principal investigators

Mary H. Samuels,  Study Chair,  Oregon Health and Science University   

Study ID Numbers:  NCRR-M01RR00334-0028; OHSU-3324
Record last reviewed:  December 2003
Last Updated:  March 23, 2005
Record first received:  October 18, 1999
ClinicalTrials.gov Identifier:  NCT00004343
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08