The diagnosis and treatment of sleep disordered breathing have come to the forefront of clinical medicine following recognition of the high prevalence and associated morbidity of sleep apnea. The effects on quality of life as well as societal costs have been well documented. The NYU Sleep Research Laboratory has spent the last several years working on the problem of improving the diagnosis of mild sleep disordered breathing which manifests as the upper airway resistance syndrome. Our approach has been to develop a non-invasive technique to detect increased upper airway resistance directly from analysis of the airflow signal. A characteristic intermittent change of the inspiratory flow contour, which is indicative of the occurrence of flow limitation, correlates well with increased airway resistance.

Currently all respiratory events are identified manually and totaled. This is time consuming and subject to variability. The objective of the present project is to improve upon the manual approach by implementing an artificially intelligent system for the identification and quantification of sleep disordered breathing based solely on non-invasive cardiopulmonary signals collected during a routine sleep study. The utility of other reported indices of sleep disordered breathing obtained during a sleep study will be evaluated.

Successful development of an automated system that can identify and classify upper airway resistance events will simplify, standardize and improve the diagnosis of sleep disordered breathing, and greatly facilitate research and clinical work in this area. Using a physiological based determination of disease should allow better assessment of treatment responses in mild disease.

Condition	Treatment or Intervention
Sleep-Disordered Breathing	Procedure: Non-invasive technique to diagnose and quantitate sleep-disordered breathing

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Patients with sleep disordered breathing

New York
      NYU Sleep Disorders Center, New York,  New York,  10016,  United States

Study ID Numbers:  NCRR-M01RR00096-0938; M01RR00096
Record last reviewed:  January 2004
Last Updated:  October 13, 2004
Record first received:  February 12, 2000
ClinicalTrials.gov Identifier:  NCT00004569
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08