Acetylcysteine |
Cysteine; L-Cysteine; N-acetylcysteine; NAC |
Acetylcysteine Systematic (IUPAC) name (R)-2-acetamido-3-mercaptopropanoic acid Identifiers CAS number 616-91-1 ATC code R05CB01 S01XA08 V03AB23 PubChem 12035 DrugBank n/a Chemical data Formula C5H9NO3S Mol. weight 163.19 Pharmacokinetic data Bioavailability 6–10% (oral) <3% (topical) Metabolism hepatic Half life 5.6 hours (adults) 11 hours (neonates) Excretion renal Therapeutic considerations Pregnancy cat. B2 (Aus) Legal status Schedule 4 ...
Wikipedia - [full article]
Acetylcysteine Clinical Trials
- An Investigation of N-Acetylcysteine and Fenoldopam As Renal Protection Agents for Cardiac Surgery
ClinicalTrials.gov Identifier: NCT00122018 - Active, not recruiting
Kidney Failure, Acute; Kidney Failure, Chronic; Cardiac surgical procedures
- N-Acetylcysteine Protects From Aminoglycosides Induced Nephrotoxicity
ClinicalTrials.gov Identifier: NCT00267384 - Recruiting
Drug Induced Nephrotoxicity; Aminoglycosides
- N-Acetylcysteine in Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00568087 - Recruiting
Alcoholism
- The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients
ClinicalTrials.gov Identifier: NCT00247507 - Active, not recruiting
Anemia; Atherosclerosis; End-Stage Renal Disease; Oxidative Stress; Pro-Inflammation
- Investigation of the Effect of N Acetylcysteine Against Anti-Tuberculosis Drugs Induced Liver Toxicity
ClinicalTrials.gov Identifier: NCT00564642 - Recruiting
Hepatitis
- Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material
ClinicalTrials.gov Identifier: NCT00558142 - Recruiting
Radiocontrast-Induced Nephropathy
- An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents
ClinicalTrials.gov Identifier: NCT00542750 - Recruiting
Cannabis Dependence
- Effects of N-Acetylcysteine on Muscle Fatigue in Hemodialysis
ClinicalTrials.gov Identifier: NCT00440869 - Recruiting
End-Stage Renal Disease; Dialysis; Hemodialysis
- Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis
ClinicalTrials.gov Identifier: NCT00525551 - Recruiting
Otosclerosis
- Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
ClinicalTrials.gov Identifier: NCT00238173 - Active, not recruiting
Bone Marrow Suppression; Brain and Central Nervous System Tumors; Drug Toxicity; Long-Term Effects Secondary to Cancer Therapy in Children
- A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
ClinicalTrials.gov Identifier: NCT00579995 - Recruiting
Preserving Kidney Function in People Who Are at High Risk of Developing Contrast-Induced Nephropathy
- High Dose Intravenous N-Acetylcysteine Versus Iloprost for Early, Rapidly Progressive Diffuse Systemic Sclerosis
ClinicalTrials.gov Identifier: NCT00428883 - Recruiting
Scleroderma, Diffuse
- A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders
ClinicalTrials.gov Identifier: NCT00453180 - Recruiting
Autistic Disorder; Asperger Syndrome; Child Development Disorders, Pervasive
- Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-Controlled Study
ClinicalTrials.gov Identifier: NCT00512265 - Recruiting
Pulmonary Morbidity
- N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)
ClinicalTrials.gov Identifier: NCT00374088 - Recruiting
Transposition of Great Vessels; Congenital Heart Disease
- N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD
ClinicalTrials.gov Identifier: NCT00539188 - Recruiting
Borderline Personality Disorder; Self-Injurious Behavior
- Homocystinuria: Treatment With N-Acetylcysteine
ClinicalTrials.gov Identifier: NCT00483314 - Recruiting
Homocystinuria
- Effect of N-Acetylcysteine on Peritoneal Membrane Function in Chronic Peritoneal Dialysis Patients
ClinicalTrials.gov Identifier: NCT00421785 - Recruiting
ESRD; Peritoneal Dialysis
- N-Acetylcysteine in Treating Cocaine Dependent Individuals - 1
ClinicalTrials.gov Identifier: NCT00136825 - Completed
Cocaine-Related Disorders
- Prevention of Contrast Nephropathy by Sodium Bicarbonate Versus Sodium Chloride and N-Acetylcysteine
ClinicalTrials.gov Identifier: NCT00353340 - Recruiting
Acute Renal Failure Contrast Nephropathy
- N-Acetylcysteine in Intra-Amniotic Infection/Inflammation
ClinicalTrials.gov Identifier: NCT00397735 - Recruiting
Labor, Premature; Preterm Premature Rupture of the Membranes; Infection; Inflammation; Chorioamnionitis
- The Effect of Administration on N-Acetylcysteine on Serum Creatinine Levels in Patients With Chronic Kidney Disease
ClinicalTrials.gov Identifier: NCT00498342 - Recruiting
Chronic Kidney Disease
- COmbined N-Acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT
ClinicalTrials.gov Identifier: NCT00497328 - Not yet recruiting
Contrast Induced Nephropathy
- N-Acetylcysteine Augmentation in Treatment-Refractory Obsessive-Compulsive Disorder
ClinicalTrials.gov Identifier: NCT00539513 - Recruiting
Obsessive-Compulsive Disorder
- Role of Acetylcysteine in Creatinine Clearance
ClinicalTrials.gov Identifier: NCT00396396 - Recruiting
Creatinine Clearance
- Randomized Study of Acetylcysteine in Patients with Acute Liver Failure Not Caused by Acetaminophen
ClinicalTrials.gov Identifier: NCT00004467 - Completed
Acute Liver Failure
- Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass.
ClinicalTrials.gov Identifier: NCT00190034 - Recruiting
Cardiovascular Disease; Renal Insufficiency, Acute; Cardiopulmonary Bypass
- Combination Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma
ClinicalTrials.gov Identifier: NCT00003346 - Active, not recruiting
stage III melanoma; Stage IV Melanoma; Recurrent Melanoma
- N-Acetylcysteine in Heart Failure With Coexistent Chronic Renal Failure
ClinicalTrials.gov Identifier: NCT00532688 - Recruiting
Heart Failure, Congestive; Kidney Failure, Chronic
- Effect of N-Acetylcysteine on Residual Renal Function in Chronic Hemodialysis Patients
ClinicalTrials.gov Identifier: NCT00507052 - Not yet recruiting
Hemodialysis; Renal Failure
- A Controlled Trial: Subjects Enrolled in the Study Receive Either NAC or Placebo. NAC is a N Acetyl Pro-Drug of the Naturally-Occurring Amino Acid Cystine. Subjects Enrolled in the Study Are Addicted to Cocaine - 1
ClinicalTrials.gov Identifier: NCT00218491 - Recruiting
Cocaine Dependence
- Effect of N-Acetylcysteine on Creatinine in Chronic Kidney Disease
ClinicalTrials.gov Identifier: NCT00506506 - Not yet recruiting
Stage 3 Chronic Kidney Disease
- Optimalization of Nephroprotection Using N-Acetylcysteine
ClinicalTrials.gov Identifier: NCT00572663 - Completed
Chronic Kidney Disease; Proteinuria
- A Study of The Effectiveness of N-Acetylcysteine in Kidney Protection Following Cardiopulmonary Bypass
ClinicalTrials.gov Identifier: NCT00187330 - Completed
Heart Disease; Renal Insufficiency
- Safety and Efficacy Study of Copaxone Administered in Combination With N-Acetylcysteine
ClinicalTrials.gov Identifier: NCT00203099 - Completed
Relapse Remitting Multiple Sclerosis
- NASPI: N-Acetylcysteine vs. Ascorbic Acid for Prevention of Contrast Induced Nephropathy in Renal Insufficiency Undergoing Coronary Catheterization
ClinicalTrials.gov Identifier: NCT00356954 - Completed
Kidney Failure
- Acetylcysteine in the Prevention of Renal Failure After Bypass Surgery
ClinicalTrials.gov Identifier: NCT00211653 - Completed
Kidney Failure
- N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
ClinicalTrials.gov Identifier: NCT00188630 - Completed
Heart Disease; Acute Renal Failure
- Efficacy of N-Acetylcysteine in Treatment of Overt Diabetic Nephropathy
ClinicalTrials.gov Identifier: NCT00556465 - Completed
Diabetic Nephropathy; Chronic Kidney Disease; Diabetes Type 2
- High-Dose N-Acetylcysteine in Cardiac Surgery
ClinicalTrials.gov Identifier: NCT00332631 - Completed
Cardiac Surgery and Cardiopulmonary Bypass
- Acetylcysteine, Theophylline, and a Combination of Both in the Prophylaxis of Contrast-Induced Nephropathy
ClinicalTrials.gov Identifier: NCT00492518 - Completed
Contrast Induced Nephropathy; Kidney Diseases; Renal Failure; Adverse Effects
- N-Acetylcysteine and Arginine Administration in Diabetic Patients
ClinicalTrials.gov Identifier: NCT00569465 - Terminated
Type 2 Diabetes Mellitus; Hypertension
- Contrast Nephropathy Prevention With N-Acetylcysteine in Acute Myocardial Infarction
ClinicalTrials.gov Identifier: NCT00237614 - Completed
Contrast-Induced Nephropathy; Acute Myocardial Infarction

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