Alpha-Lipoic Acid |
dihydrolipoic acid; lipoic acid; lipolate; thiotic acid |
Chemical structure of lipoic acid Chemical structure of dihydrolipoic acid Lipoic acid or α-lipoic acid (alpha lipoic acid) has formula C8H14S2O2 and systematic name 5-(1,2-dithiolan-3-yl)pentanoic acid. Dihydrolipoic acid or reduced lipoic acid has formula C8H16S2O2 and systematic name 6,8-disulfanyloctanoic acid. It is sometimes called lipoic acid. Thioctic acid and dihydrothioctic acid are synonyms respectively Lipoate is the unprotonated base and this form is mainly present ...
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Alpha-Lipoic Acid Clinical Trials
- Painful HIV Neuropathy and Alpha-Lipoic Acid
ClinicalTrials.gov Identifier: NCT00079807 - Active, not recruiting
HIV; Peripheral Neuropathy
- Alpha Lipoic Acid and Polycystic Ovary Syndrome
ClinicalTrials.gov Identifier: NCT00505427 - Recruiting
Insulin Resistance; Oxidative Stress
- Provision of Antioxidant Therapy in Hemodialysis (PATH) Study
ClinicalTrials.gov Identifier: NCT00237718 - Recruiting
End Stage Renal Disease
- Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin
ClinicalTrials.gov Identifier: NCT00477607 - Recruiting
Ototoxicity; Unspecified Adult Solid Tumor, Protocol Specific
- Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin
ClinicalTrials.gov Identifier: NCT00570596 - Recruiting
Ototoxicity; Unspecified Adult Solid Tumor, Protocol Specific
- Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus
ClinicalTrials.gov Identifier: NCT00187564 - Active, not recruiting
Diabetes Mellitus, Type 1
- Immune Restoration by Lipoic Acid in AIDS
ClinicalTrials.gov Identifier: NCT00033176 - Completed
Acquired Immunodeficiency Syndrome; HIV Infections
- Tocopherols and Alpha Lipoic Acid Treatment Chronic Kidney Disease (TALAT)
ClinicalTrials.gov Identifier: NCT00308971 - Active, not recruiting
Chronic Kidney Disease
- Anti-Oxidant Treatment of Alzheimer''s Disease
ClinicalTrials.gov Identifier: NCT00117403 - Active, not recruiting
Alzheimer''s Disease
- An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes
ClinicalTrials.gov Identifier: NCT00116207 - Recruiting
Diabetic Autonomic Neuropathy
- Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00090402 - Completed
Alzheimer's Disease; Oxidative Stress; Dementia; Hyperlipidemia; Inflammation
- CVD Risk and Prevention in Early Glucose Intolerance
ClinicalTrials.gov Identifier: NCT00122447 - Recruiting
Impaired Glucose Tolerance (IGT)
- Antioxidant Functions of Lipoic Acid
ClinicalTrials.gov Identifier: NCT00065624 - Completed
Hypercholesterolemia
- Alpha Lipoic Acid for Burning Mouth
ClinicalTrials.gov Identifier: NCT00387543 - Completed
Burning Sore Mouth
- Effect of Long Term α-Lipoic Acid Treatment on Endothelial Function in Patients With Type 2 Diabetes
ClinicalTrials.gov Identifier: NCT00490867 - Active, not recruiting
Type 2 Diabetes
- Natural Antioxidants in the Treatment of Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00010842 - Completed
Multiple Sclerosis
- The Effects of Lipoic Acid on Glycaemic Control in Type 2 Diabetes
ClinicalTrials.gov Identifier: NCT00398892 - Not yet recruiting
Diabetes Mellitus, Type 2
- 4-PBA: Will it increase the level of Alpha 1-Antitrypsin(AAT) in persons with AAT deficiency?
ClinicalTrials.gov Identifier: NCT00067756 - Active, not recruiting
alpha 1-Antitrypsin Deficiency
- Genetics of Alpha Thalassemia in Israeli Ethnic Groups
ClinicalTrials.gov Identifier: NCT00159029 - Recruiting
alpha Thalassemia
- Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon
ClinicalTrials.gov Identifier: NCT00226408 - Recruiting
Adjuvant; Stage III Malignant Melanoma; Interferon Alpha; Therapy
- Alpha-1 Coded Testing Study (ACT Trial)
ClinicalTrials.gov Identifier: NCT00500123 - Recruiting
Alpha 1-Antitrypsin Deficiency
- Alpha-1 Foundation Research Registry
ClinicalTrials.gov Identifier: NCT00499941 - Recruiting
Alpha 1-Antitrypsin Deficiency
- Efficacy and Safety Study of Augmentation Therapy With Aralast (Human Alpha 1 - Proteinase Inhibitor)
ClinicalTrials.gov Identifier: NCT00396006 - Recruiting
Alpha 1-Antitrypsin Deficiency
- Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00377416 - Active, not recruiting
Alpha 1-Antitrypsin Deficiency
- ABR-217620 With Interferon-Alpha (IFN-Alpha) Compared to IFN-Alpha Alone in Patients With Advanced Renal Cell Carcinoma
ClinicalTrials.gov Identifier: NCT00420888 - Recruiting
Renal Cell Carcinoma
- Safety and Efficacy of Recombinant Human Acid Alpha-Glucosidase in the Treatment of Classical Infantile Pompe Disease
ClinicalTrials.gov Identifier: NCT00025896 - Completed
Pompe Disease; Glycogen Storage Disease Type II; Acid Maltase Deficiency Disease; Glycogenosis 2
- Use of Flaxseed(Alpha Linolenic Acid) Powder in Morbidly Obese Patients With Systemic Inflammation
ClinicalTrials.gov Identifier: NCT00502021 - Not yet recruiting
Morbid Obesity; Atherosclerosis; Systemic Inflammation
- Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00430768 - Recruiting
Alpha 1-Antitrypsin Deficiency
- The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00532805 - Recruiting
Alpha-1 Antitrypsin Deficiency
- Activity of Essential Fatty Acid Elongation/Desaturation Pathway During Early Life in Human Infants, In Vivo
ClinicalTrials.gov Identifier: NCT00342303 - Active, not recruiting
Fatty Acid Metabolism
- A study to compare the efficacy of intravenous loading doses followed by maintenance treatment with oral ibandronic acid versus zoledronic acid in patients with skeletal metastases experiencing moderate to severe pain.
ClinicalTrials.gov Identifier: NCT00099177 - Active, not recruiting
Pain; Bone Neoplasms; Neoplasm Metastasis
- The Natural History of Alpha-Mannosidosis
ClinicalTrials.gov Identifier: NCT00498420 - Recruiting
Alpha Mannosidosis
- A study to compare the efficacy of intravenous loading doses followed by maintenance treatment with intravenous ibandronic acid versus zoledronic acid in patients with skeletal metastases experiencing moderate to severe pain.
ClinicalTrials.gov Identifier: NCT00099203 - Active, not recruiting
Pain; Bone Neoplasms; Neoplasm Metastasis
- Relationship Between Folic Acid and Warfarin Metabolism and Effect
ClinicalTrials.gov Identifier: NCT00162409 - Recruiting
Folic Acid Deficiency
- Ingested Interferon Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Type 1 Diabetes Mellitus
ClinicalTrials.gov Identifier: NCT00005665 - Active, not recruiting
Diabetes Mellitus, Type 1
- Interferon-Alpha for Diabetes Mellitus Type 1
ClinicalTrials.gov Identifier: NCT00024518 - Active, not recruiting
Insulin-Dependent Diabetes Mellitus
- DHA (Docosahexaenoic Acid), an Omega 3 Fatty Acid, in Slowing the Progression of Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00440050 - Active, not recruiting
Alzheimer's Disease
- Double-Blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis)
ClinicalTrials.gov Identifier: NCT00145327 - Active, not recruiting
Osteoporosis
- Folic Acid and Omega -3 Fatty Acid Supplementation in Depressed Older Adults
ClinicalTrials.gov Identifier: NCT00480207 - Recruiting
Depression
- Therapy of Early Chronic Phase Chronic Myelogenous Leukemia with Gleevec, Alpha Interferon, and Ara-C
ClinicalTrials.gov Identifier: NCT00048672 - Active, not recruiting
Leukemia, Myeloid, Chronic-Phase
- On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication
ClinicalTrials.gov Identifier: NCT00161096 - Active, not recruiting
Chronic Use of Acid Suppressive Medication; GORD; GERD; Reflux; Peptic Ulcer
- Efficacy of Prazosin Versus Placebo Associated with Peg-Interferon Alpha 2b and Ribavirin in Chronic Hepatitis C with Genotype 1 or 4 and Severe Fibrosis
ClinicalTrials.gov Identifier: NCT00148837 - Active, not recruiting
Hepatitis C, Chronic; Fibrosis
- Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer
ClinicalTrials.gov Identifier: NCT00045006 - Active, not recruiting
Cancer
- Therapy of Early Chronic Phase Chronic Myelogenous Leukemia (CML) with Higher-Dose Gleevec, Alpha Interferon, and Low-Dose Ara-C
ClinicalTrials.gov Identifier: NCT00038649 - Active, not recruiting
Myelogenous Leukemia, Chronic, Chronic Phase
- Long-term Peginterferon alpha-2a Plus Ribavirin to Treat Chronic Hepatitis C in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00076765 - Recruiting
Hepatitis C; HIV Infections
- Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00157092 - Completed
alpha 1-Antitrypsin Deficiency
- Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)
ClinicalTrials.gov Identifier: NCT00000621 - Active, not recruiting
Emphysema; Lung Diseases; Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease
- Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00460096 - Completed
Alpha 1-Antitrypsin Deficiency
- Effect of Polyunsaturated Fatty Acids on Cardiovascular and Motor Responses Under Stress
ClinicalTrials.gov Identifier: NCT00014027 - Recruiting
Healthy
- Efficacy and Safety of Zoledronic Acid in the Prevention of Bone Loss in Postmenopausal Women with Osteopenia, 45 Years of Age and Older.
ClinicalTrials.gov Identifier: NCT00132808 - Active, not recruiting
Osteopenia (osteoporosis prevention)
- Randomized Phase Iii-Study On Valproic Acid In Combination With All-Trans Retinoic Acid, Standard Induction- And Consolidation Therapy In Older Patients With Newly Diagnosed Acute Myeloid Leukemia
ClinicalTrials.gov Identifier: NCT00151255 - Recruiting
Acute myeloid leukemia, age > 60 years
- Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole
ClinicalTrials.gov Identifier: NCT00542347 - Recruiting
Gastric Acid
- Aralast alpha1-Proteinase Inhibitor Surveillance Study
ClinicalTrials.gov Identifier: NCT00313144 - Active, not recruiting
Alpha 1-Antitrypsin Deficiency
- The Effect of Folic Acid on Efficacy of Sulfadoxine-Pyrimethamine in Pregnant Women in Western Kenya
ClinicalTrials.gov Identifier: NCT00130065 - Active, not recruiting
Malaria
- Randomized Phase Ii-Study On Valproic Acid, All-Trans Retinoic Acid And Their Combination In Induction And Consolidation Therapy As Well As Pegfilgrastim After Consolidation Therapy In Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
ClinicalTrials.gov Identifier: NCT00151242 - Recruiting
Acute Myeloid Leukemia
- A Study of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients with Solid Tumors
ClinicalTrials.gov Identifier: NCT00127127 - Active, not recruiting
Tumors
- Controlled Trial of 4-Aminosalicylic Acid in Patients with Small Bowel Crohn's Disease
ClinicalTrials.gov Identifier: NCT00004423 - Active, not recruiting
Crohn's Disease
- Study of Docosahexaenoic Acid (DHA) Supplementation in Patients with X-Linked Retinitis Pigmentosa
ClinicalTrials.gov Identifier: NCT00004827 - Active, not recruiting
Retinitis Pigmentosa
- Beta-Carotene and Alpha-Tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
ClinicalTrials.gov Identifier: NCT00169845 - Active, not recruiting
Neoplasms
- An Investigational Drug Study with Suberoylanilide Hydroxamic Acid in Relapsed Diffuse Large B-cell Lymphoma
ClinicalTrials.gov Identifier: NCT00097929 - Active, not recruiting
B-Cell Lymphoma
- Peginterferon alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00018031 - Recruiting
Hepatitis C; HIV Infections
- The Safety and Tolerability of Alpha-1 MP in Subjects With Alpha-1-Antitrypsin (AAT) Deficiency.
ClinicalTrials.gov Identifier: NCT00301366 - Completed
Alpha 1-Antitrypsin Deficiency
- Safety and Efficacy Trial with Zoledronic Acid for the Treatment of Paget's Disease of Bone
ClinicalTrials.gov Identifier: NCT00103740 - Active, not recruiting
Paget's Disease of Bone
- Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial
ClinicalTrials.gov Identifier: NCT00522262 - Active, not recruiting
Breast Neoplasms
- Pegylated Interferon-Alpha-2a in Patients With Malignant Melanoma Stage IIA-IIIB
ClinicalTrials.gov Identifier: NCT00204529 - Active, not recruiting
Melanoma
- Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects with Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00161707 - Completed
alpha 1-Antitrypsin Deficiency
- Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants
ClinicalTrials.gov Identifier: NCT00004410 - Recruiting
Cholestasis
- A Study of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients with Malignant Lymphoma
ClinicalTrials.gov Identifier: NCT00127140 - Active, not recruiting
Malignant Lymphoma
- PEG Interferon Alpha 2B and Low-Dose Ara-C in Early Chronic Phase CML
ClinicalTrials.gov Identifier: NCT00303290 - Active, not recruiting
Chronic Myeloid Leukemia
- Suberoylanilide Hydroxamic Acid in Treating Patients With Relapsed Non-Hodgkin''s Lymphoma
ClinicalTrials.gov Identifier: NCT00124631 - Active, not recruiting
recurrent adult diffuse large cell lymphoma
- High-Dose Folic Acid in Preventing Colorectal Cancer in Patients Who Have Had Polyps Surgically Removed
ClinicalTrials.gov Identifier: NCT00002650 - Active, not recruiting
Rectal Cancer; prevention of colorectal cancer; Colon Cancer
- Omega-3 Fatty Acid Status in Morbid Obesity Before and After Surgical Treatment
ClinicalTrials.gov Identifier: NCT00558532 - Recruiting
Morbid Obesity; Cardiovascular Disease; Fatty Acid Levels
- Suberoylanilide Hydroxamic Acid and Capecitabine in Treating Patients with Metastatic Or Unresectable Solid Tumors
ClinicalTrials.gov Identifier: NCT00121277 - Active, not recruiting
unspecified adult solid tumor, protocol specific
- The Role of Vitamins E and C in Maintaining Lung Health in People with Asthma
ClinicalTrials.gov Identifier: NCT00142610 - Active, not recruiting
Asthma
- Valproic Acid in Treating Patients With Kaposi's Sarcoma
ClinicalTrials.gov Identifier: NCT00075777 - Active, not recruiting
recurrent Kaposi's sarcoma; epidemic Kaposi's sarcoma
- Lactic Acid in the Rectum and Life-Threatening Infection.
ClinicalTrials.gov Identifier: NCT00197938 - Recruiting
Septic Shock
- Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Solid Tumors That Have Not Responded to Previous Therapy
ClinicalTrials.gov Identifier: NCT00005634 - Active, not recruiting
Leukemia; Lymphoma; Prostate Cancer; Multiple Myeloma; Eye Cancer
- Low-Dose IL-2 Plus IFN-Alpha Immunotherapy as Adjuvant Treatment of Renal Carcinoma.
ClinicalTrials.gov Identifier: NCT00502034 - Active, not recruiting
Carcinoma, Renal Cell
- Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal Cancer
ClinicalTrials.gov Identifier: NCT00445523 - Active, not recruiting
Carcinoma, Renal Cell
- A study of the safety and pharmacokinetics of rhGAA in siblings with Glycogen Storage Disease Type II
ClinicalTrials.gov Identifier: NCT00051935 - Completed
Glycogen Storage Disease Type II; Pompe Disease; Acid Maltase Deficiency Disease; Glycogenosis 2
- Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
ClinicalTrials.gov Identifier: NCT00342992 - Active, not recruiting
Lung Cancer; Prostatic Neoplasms; Prostate Cancer; Pancreatic Cancer
- Dimethylxanthenone Acetic Acid in Treating Patients With Solid Tumors
ClinicalTrials.gov Identifier: NCT00003697 - Active, not recruiting
unspecified adult solid tumor, protocol specific
- 48 Weeks Combination Therapy for Patients with HBeAg-negative Chronic Hepatitis B Virus (HBV) Infection
ClinicalTrials.gov Identifier: NCT00114361 - Active, not recruiting
Hepatitis B
- Pilot Study to Evaluate Nucleic Acid Amplification Methods in the Diagnosis and Management of Active TB
ClinicalTrials.gov Identifier: NCT00023439 - Recruiting
Tuberculosis
- Study to Evaluate Viral Kinetics in the First 12 Weeks of Patients With Hepatitis C Coinfected With HIV Treated With Induction Doses of Peginterferon Alpha-2a (40 KD) and Ribavirin With Epoetin β Support
ClinicalTrials.gov Identifier: NCT00356486 - Active, not recruiting
HIV Infections
- The Role of 5-Alpha Reductase in Mediating Testosterone Actions
ClinicalTrials.gov Identifier: NCT00493987 - Recruiting
Healthy
- Study of Treatment and Metabolism in Patients With Urea Cycle Disorders
ClinicalTrials.gov Identifier: NCT00004307 - Recruiting
Amino Acid Metabolism, Inborn Errors
- Study of Zoledronic Acid for Patients With Hormone-Sensitive Bone Metastases From Prostate Cancer
ClinicalTrials.gov Identifier: NCT00242567 - Recruiting
Prostate Cancer
- Suberoylanilide Hydroxamic Acid in Treating Patients With Recurrent or Persistent Ovarian Epithelial or Primary Peritoneal Cancer
ClinicalTrials.gov Identifier: NCT00132067 - Active, not recruiting
recurrent ovarian epithelial cancer; peritoneal cavity cancer
- Higher Frequency Zoledronic Acid in the Treatment of Multiple Myeloma
ClinicalTrials.gov Identifier: NCT00263484 - Recruiting
Multiple Myeloma
- Ursodesoxycholic Acid in the Treatment of Duodenal Adenomas in FAP Patients.
ClinicalTrials.gov Identifier: NCT00134758 - Recruiting
Adenomatous Polyposis Coli; Adenoma
- Study of Zoledronic Acid Administered Monthly Versus Every 3 Months in Multiple Myeloma and Breast Cancer Patients Who Were Treated With Zoledronic Acid the Prior Year
ClinicalTrials.gov Identifier: NCT00424983 - Recruiting
Multiple Myeloma; Breast Cancer
- Clinical and Laboratory Study of Methylmalonic Acidemia
ClinicalTrials.gov Identifier: NCT00078078 - Recruiting
Amino Acid Metabolism; Inborn Errors
- Investigating the Role of Norepinephrine in Emotional Processing through Alpha-2 Adrenergic Receptor Modulation
ClinicalTrials.gov Identifier: NCT00109642 - Recruiting
- Phase I Study of Alpha-Melanocyte Stimulating Hormone in Patients with Acute Renal Failure
ClinicalTrials.gov Identifier: NCT00004496 - Recruiting
Acute Renal Failure
- Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux
ClinicalTrials.gov Identifier: NCT00231881 - Recruiting
Gastro-Oesophageal Reflux
- Safety Study of rhASM Enzyme Replacement Therapy in Adults With Acid Sphingomyelinase Deficiency (Niemann-Pick Disease)
ClinicalTrials.gov Identifier: NCT00410566 - Recruiting
Acid Sphingomyelinase Deficiency; Niemann-Pick Disease
- Paclitaxel, Folic Acid, and Lometrexol in Treating Patients With Locally Advanced or Metastatic Solid Tumors
ClinicalTrials.gov Identifier: NCT00024310 - Active, not recruiting
Drug Toxicity; unspecified adult solid tumor, protocol specific
- Total Therapy II
ClinicalTrials.gov Identifier: NCT00083551 - Active, not recruiting
Multiple Myeloma
- Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes, Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a
ClinicalTrials.gov Identifier: NCT00199732 - Active, not recruiting
Chronic Hepatitis B

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