Not Signed In -
Alpha-Lipoic Acid |
dihydrolipoic acid; lipoic acid; lipolate; thiotic acid |
Clinical Trial: Antioxidant Functions of Lipoic Acid
This study is currently recruiting patients.
|
Purpose
The goal of this study is to determine whether a short treatment with lipoic acid, an antioxidant used in the treatment of diabetic neuropathy, improves blood vessel reactivity and decreases oxidant stress in persons with elevated blood cholesterol.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Hypercholesterolemia | Drug: lipoic acid | Phase II |
MedlinePlus related topics: Cholesterol
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Further Study Details:
Expected Total Enrollment: 16
Study start: November 2003; Expected completion: February 2005
Eligibility
Ages Eligible for Study: 50 Years - 75 Years, Genders Eligible for Study: Both
Criteria
Inclusion criteria:
- Lipid criteria for inclusion are a plasma LDL between 160 and 190 mg/dl (total cholesterol usually 240-285 mg/dl)
- Less than 2 coronary risk factors, and already on a cholesterol-lowering diet.
Exclusion criteria:
- Overt or clinical atherosclerosis
- Diabetes
- Currently taking cholesterol-lowering medication.
- Subjects with other lipid disorders
- Subjects taking supplemental lipoic acid, vitamin C, or vitamin E.
Location and Contact Information
James M May, MD 615-936-1653 james.may@vanderbilt.edu
Tennessee
Vanderbilt University Medical Center, Nashville, Tennessee, 37232, United States; Recruiting
Anup Sabharwal, MD 615-936-1727 anup.sabharwal@vanderbilt.edu
Study chairs or principal investigators
James M May, MD, Principal Investigator, Vanderbilt University Medical Center
More Information
Study ID Numbers: R21 AT001062-01A2
Record last reviewed: September 2004
Last Updated: October 13, 2004
Record first received: July 29, 2003
ClinicalTrials.gov Identifier: NCT00065624
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Record last reviewed: September 2004
Last Updated: October 13, 2004
Record first received: July 29, 2003
ClinicalTrials.gov Identifier: NCT00065624
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
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