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Classification of common diuretics and their mechanisms of action agent mechanism Potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene) inhibition within collecting ducts of Na+-K+ exchange: spironolactone inhibits aldosterone action; amiloride inhibits epithelial sodium channels (ENaC) water inhibits vasopressin secretion ethanol inhibits vasopressin secretion V2 vasopressin receptor antagonists inhibit vasopressin's action on nephron's collecting duct X ...
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