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Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance - Article


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Clinical Trial: Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance

This study is currently recruiting patients.

Sponsored by: Department of Veterans Affairs
Information provided by: Department of Veterans Affairs

Purpose

The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.

Condition Treatment or Intervention
Post-Traumatic Stress Disorder
 Behavior: Imagery Rehearsal
 Behavior: Sleep and Nightmare Management

MedlinePlus related topics:  Post-Traumatic Stress Disorder

Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study

Official Title: 7857 Cognitive - Behavioral Treatments for PTSD Sleep Disturbance

Further Study Details: 

Expected Total Enrollment:  150

Study start: April 2004;  Expected completion: January 2007

Repetitive, stereotypical nightmares and insomnia commonly characterize post-traumatic stress disorder (PTSD). Identifying the pathophysiological mechanisms of disrupted sleep in PTSD has therefore assumed considerable clinical importance. We previously reported an increase in rapid eye movement activity (REM activity) during REM sleep (REMS) in Vietnam War combat veterans with PTSD, and this finding can be seen as consistent with the view that most, although not all, dreaming occurs during REMS and the repeated observation that REM activity correlates with the intensity of dream mentation. There is a growing body of evidence that post-traumatic nightmares can respond to psychological treatment interventions. Namely, a cognitive-behavioral technique entitled imagery rehearsal (IR) has been reported to be effective in the treatment of such nightmares in victims of crime and in women who have been sexually assaulted. In a small pilot study, it has also been reported to be effective in the treatment of Vietnam veterans with combat-related PTSD. The two objectives of this proposal are: 1. To compare, in a study with random assignment and a parallel group design, the effectiveness in controlling the subjective sleep disturbance in veterans with PTSD of IR and Sleep and Nightmare Management (SN), a psychological treatment that targets life stressors and problems with sleep hygiene that may exacerbate insomnia and nightmares. 2. In a subset of these subjects, to compare the effectiveness in reducing REM activity of IR and SN.

Eligibility

Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

  • Male
  • Vietnam Combat Veteran
  • Diagnosis of combat-related PTSD
  • Stable psychotropic regimen for a minimum of three months
  • Experiences recurrent nightmares

Exclusion Criteria:

  • Bipolar disorder, delirium, dementia, amnestic and other cognitive disorders
  • Schizophrenia and other psychotic disorders
  • Substance abuse or dependence within the last six months
  • Untreated medical disorders known to impact sleep

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00108628


Pennsylvania
      VA Medical Center, Philadelphia,  Pennsylvania,  19104,  United States; Recruiting
Richard Ross, M.D., Ph.D.  215-823-4046    ross_r@mail.trc.upenn.edu 
Joan Cook, Ph.D.,  Principal Investigator
Richard Ross, M.D., Ph.D.,  Principal Investigator

More Information

Study ID Numbers:  CLIN-018-03S
Record last reviewed:  April 2005
Last Updated:  April 15, 2005
Record first received:  April 15, 2005
ClinicalTrials.gov Identifier:  NCT00108628
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-05-03


Source: ClinicalTrials.gov
Cache Date: May 4, 2005


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October 11, 2008



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